Home     فارسی  
   [Home ] [Archive]    
:: Volume 10, Issue 1 (vol.10,no.1 2012) ::
G3M 2012, 10(1): 2675-2683 Back to browse issues page
Beta Thalasemia: Epidemiology, Diagnostic and Treatment Approach in Iran
Najeddin Saki , Ali Dehghani Fard , Saeid Kaviani , Mohammad Ali Jalali Far , Seyed Hadi Mousavi , Kheirollah AL _Ali , Fakher Rahim
Abstract:   (9577 Views)

Beta thalassemia is most monogenic disorders with autosomal recessive inheritance in worldwide. In this article we reviewed fifty articles about epidemiology and diagnostic and treatment procedures of beta thalassemia during 1982- 2011 and emphasis the attention to different diagnostic nad treatment procedures in Iran. Beta thalassemia is more prevalent in sea coast especially Mediterranean sea. In Iran, more cases of beta thalassemia were found in Caspian Sea and Persian Gulf regions. Also other regions including Isfahan, Fars and Bushehr have significant thalassemic patients. The IVS II-1 mutation is most prevalent variant in different regions of Iran. The diagnostic tests based on PCR play great role in identification of new mutations, heterozygote patients and pre-natal diagnosis. The molecular methods are selected depending on the mutation. Given the importance of early treatment of thalassemic patients, screening and identification of affected people is so important. At now, the common therapeutic approaches of beta thalassemia are transfusion and ferrochellator drugs. The definitive treatment of patients in case of finding HLA matched donors are bone marrow transplantation.

Keywords: Beta-thalassemia, Mutation, Treatment, Molecular diagnosis, Bone marrow transplantation
Full-Text [PDF 761 kb]   (3952 Downloads)    
Type of Study: Review | Subject: General
Received: 2012/09/20 | Accepted: 2016/12/18 | Published: 2016/12/18
Add your comments about this article
Your username or Email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Saki N, Dehghani Fard A, Kaviani S, Jalali Far M A, Mousavi S H, AL _Ali K et al . Beta Thalasemia: Epidemiology, Diagnostic and Treatment Approach in Iran. G3M. 2012; 10 (1) :2675-2683
URL: http://g3m.ir/article-1-523-en.html
Volume 10, Issue 1 (vol.10,no.1 2012) Back to browse issues page
ژنتیک در هزاره سوم Genetics in the 3rd millennium
Persian site map - English site map - Created in 0.051 seconds with 815 queries by yektaweb 3535